This is the first time in 31 games over 15 years that the N.F.L. has sent two winning teams to play each other in London. It’s also the first time they have sent the Packers, who are 8.5-point favorites on the neutral field. They face the Giants and the league’s top running back, Saquon Barkley, who stepped up last week and took snaps late in the game when both Giants quarterbacks went out with injuries. The Giants have said they are “optimistic” Daniel Jones will be ready to play in London. There is also hope that wide receivers Wan’Dale Robinson and Kadarius Toney will come off the injury list this week. If all of them play and are healthy, the Giants will be more than capable of covering 8.5 points. If none of them play, the Giants will need Barkley to do a lot more than take a few snaps. Pick: Giants +8.5
Cincinnati Bengals (2-2) at Baltimore Ravens (2-2)
8:20 p.m., NBC
Line: Ravens -3 | Total: 48
The Ravens have two close losses against good teams and trailed for a total of 14 seconds in those two games. Last week, they went for it on fourth and goal from the 2-yard line rather than kicking a field goal, a decision that frustrated fans but was statistically the correct play, according to N.F.L. Next Gen Stats. Ravens Coach John Harbaugh is known for aggressive plays like this because he has confidence in his team. The Bengals are coming off a prime-time win against the Dolphins, a game that will most likely buoy their own confidence. The line is 3 in some places and 3.5 in others, and the prices are shaded to encourage bettors to either take the 3 or lay the 3.5, indicating the true number is somewhere in between. Pick: Ravens -3
Miami Dolphins (3-1) at New York Jets (2-2)
1 p.m., CBS
Line: Dolphins -3.5 | Total: 44
Tua Tagovailoa’s ugly injury last week in Miami’s loss to the Bengals has sparked a lot of necessary discussion about concussions and the dangers that players in the N.F.L. face. It’s unclear when he might play again. Miami’s backup quarterback, Teddy Bridgewater, is no rookie. He’s an eighth-year veteran with over 14,000 passing yards. The Jets are also getting used to a new quarterback. Zach Wilson got his first start of this season for the Jets last week in their win against the Steelers. In addition to throwing for 252 yards, he also managed to catch a touchdown pass. We know a lot about what Bridgewater can do. We don’t know quite as much about Wilson in the N.F.L. Pick: Jets +3.5
Pittsburgh Steelers (1-3) at Buffalo Bills (3-1)
1 p.m., CBS
Line: Bills -14 | Total: 47
Rookie quarterback Kenny Pickett took over for Mitch Trubisky last week during the Steelers’ loss to the Jets. Despite throwing three interceptions in his debut, Pickett gets the starting job this week. The market is not yet convinced that Pickett is much of an upgrade — the Bills are currently 14-point favorites. That’s a big number and enough to attract 65 percent of the money so far on Pittsburgh. The Bills are coming off back-to-back closely fought games that may have taken a lot out of them. The Steelers are 0-7 without T.J. Watt in the lineup. Pick: Bills -14
Philadelphia Eagles (4-0) at Arizona Cardinals (2-2)
4:25 p.m., Fox
Line: Eagles -5.5 | Total: 49.5
The Cardinals are coming off a win on the road against the Panthers. This week, they try to get their first win at home, but they face the undefeated Eagles. The Eagles continue to score most of their points in the second quarter, then hang on through the second half. They’ve been outscored 36-23 in the second half through four games. Arizona, on the other hand, has outscored its opponents 66-37 in the second half. The Cardinals are a team used to playing from behind. If the Eagles try to chew the clock in the second half with a nice lead, don’t be surprised if Kyler Murray takes the Cardinals down the field for a late backdoor cover. Pick: Cardinals +5.5
